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J.de SchepperE.Bierma-ZeinstraS.HofmanA.et al (2011)

The copper binding occurs through the histidine imidazole nitrogen and the terminal amine, forming a square planar coordination complex that is the functional unit

The Semax literature establishes the concentration range at which this chemical family has been studied at all roughly the 0.1% to 1% window for intranasal solutions, and micrograms-to-low-milligrams total daily amounts in human clinical settings